The future High Representative of the Union for Foreign Affairs and Security Policy and Vice President of the European Commission, Federica Mogherini, is about to start her work in a challenging environment for international relations. Russia with the invasion of Ukraine has brought back memories of an era when international law was still only a non-binding rule to manage international order, and ISIS is clearly conducting mass atrocities under the eyes of the international community. In this ECIA Briefing Enzo Maria Le Fevre Cervini, ECIA Fellow, agues that beside the emergencies, the roles for the Italian Foreign Minister, now representing the Italian Presidency of the EU, and future EU High Representative are multiple and complex. Will she be willing and able to make a shift in the world of the EU international relations? Her current and past experience are conveying unprecedented hopes on a more effective EU foreign policy. What is sure is that the EEAS is ready to take the challenges if accompanied by a cooperative and cohesive team in the next EU Commission.